Antimony trioxide is classified as a carcinogen in the state of California. Eye and eye lid inflammation (Conjuctivitis, , Keratitis). The toxicity of antimony trioxide is topical because it is a likely byproduct of the combustion of some materials "fireproofed" with antimony compounds. 0000005517 00000 n SAFETY DATA SHEET Creation Date 22-Dec-2009 Revision Date 18-Jan-2018 Revision Number 5 1. Low doses cause headaches, nausea, dizziness and depression. 23 0 obj <> endobj ; Proposition 65 requires businesses to determine if they must provide a warning about significant exposure to listed chemicals. H��T]o�0}ϯ��I������-�2��QWk7�! Antimony Review Pulmonary Toxicity Cancer Genotoxicity Mechanism ABSTRACT Although occupational exposure to antimony and its compounds can produce pulmonary toxicity, human car-cinogenic impacts have not been observed. The information is not presented with the intention to treat or diagnose any disease or condition. 0000009329 00000 n xref d_AO� (!�R�6Ni��r�r=���;Ћ��v:����EJ"���aJĢY���c3��0��S2� �� D1�!�W�K��������Bƒ72A�P�P����E�G�ء��z�R+鱔Ţ1#���d�I�--�V}�L`�ʾ��b�7�Y��;:��T��AOZw������'���*�;�z���� �J8ʨ�m�]�'���v{�a��"�UQCq_�vph��)kX�e�۔k����)%Jb'�u�Ⱥ�_iGm��v(dL�{�Q*k�#q+ C��ި�m���@�kX��)����� This site is a comprehensive resource for information regarding heavy metal toxicity and chelation therapy. Inhalation of antimony trioxide (and similar poorly soluble Sb(III) dust particles such as antimony dust) is considered harmful and suspected of causing cancer. Acute (short-term) exposure to antimony by inhalation in humans results in effects on the skin and eyes. Carcinogenicity ACGIH classifies antimony trioxide as TLV-A2 suspected human carcinogen. The effects are hypothesized to be attributed to inhalation of poorly solubl… 0000006747 00000 n In addition antimony trioxide is possibly carcinogenic to humans. 47 0 obj <>stream Antimony trioxide is a white crystalline solid. 0000003037 00000 n Antimony Toxicity 1309-64-4 - GHPGOEFPKIHBNM-UHFFFAOYSA-N - Antimony trioxide - Similar structures search, synonyms, formulas, resource links, and other chemical information. Uses advised against Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet are not met since there is an absence of consistent identifiable toxic effects other than the non-specific PSP overload, which is an adaptive response not triggering a STOT classification. 0000007824 00000 n A silt-loam soil (pH 7.0, background 0.005 mmol Sb kg−1) was amended with Sb2O3 at various concentrations. In large doses it causes irritation of the lining of the alimentary tract, resembling arsenic poisoning. Skin sensitising (Ss) – Recognised skin sensitiser: comes from a harmonised C&L classifying the substance as Skin Sens. Gastrointestinal toxicity Ingestion of a substantial quantity of antimony trioxide may result in nausea, vomiting and diarrhoea. Antimony trioxide is known to pass into breast milk and to transverse the placenta only in very small amounts. Subsequently, an inhalation oncogenicity study was conducted at exposure levels of … Antimony is usually mixed with other metals such as lead and zinc to form mixtures of metals called alloys. (IARC) (1989) concluded that antimony trioxide is possibly carcinogenic to humans (Group 2B), based on sufficient evidence in animals and inadequate evidence in humans. Inhalation studies with respirable antimony trioxide … A second group of people at risk for antimony exposure is patients suffering from schistosomiasis and leishmaniasis. Sudden infant death syndrome (SIDS) has also been found to be associated with antimony poisoning. 0000003918 00000 n The toxicity of antimony trioxide is topical because it is a likely byproduct of the combustion of some materials "fireproofed" with antimony compounds. 0000002466 00000 n x�b```�\V�� ��ea��������8��"PԌ�����Ɩ…g �L,� k�x��R��\P�Ł�����5 j� �n )��Ȟ�ŀX�D���Q�Ƀ�C���!��C�X�цx���f!�S<7D*�)p��5XB��H3�-�8F� ���@� � "� <]>> Everyone is exposed to low levels of antimony in the environment. Introduction. CAS number: 7440-36-0 (Metal) NIOSH REL: 0.5 mg Sb/m3 TWA Current OSHA PEL: 0.5 mg Sb/m3 TWA 1989 OSHA PEL: Same as current PEL 1993-1994 ACGIH TLV: 0.5 mg Sb/m3 TWA Description of substance: Varies Original (SCP) IDLH: 80 mg Sb/m3 Basis for original (SCP) IDLH: AIHA [1959] reported that the severity of hazard is moderate to high for both acute and chronic exposures to antimony … %%EOF 0000004671 00000 n The guidelines for maximum permissible levels of antimony in drinking water are as follows: Remove the individual from the toxic environment. Over fifty people were "very sick" and treated in hospital after drinking lemonade contaminated with 13 mg/L antimony. However, these effects are only observed with female rats and after long-term exposure to high dust concentrations. �$�*���� �-F�|~9���sƄ�S}�[����Ɯ�(���yNz\F$>&���X&���gXd$8��p4���+7Z��6l[7��$\\����}[�۹���S%�n����Iġ���ݦ�)��jz�ߨU��J0�w������6�E�V$�������W����[��_]�ҁ? Antimony spots (from vapor) Scaly Skin, Chickenpox, Blisters; Diarrhea, Vomiting, Digestive Upset; Hypovolemic Shock; Eye and eye lid inflammation (Conjuctivitis, , Keratitis) Chronic exposure can lead to; antimony pneumonia, alterations in lung function, chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural … Antimony is a silvery grey metalloid. 0000001994 00000 n 0000012811 00000 n Exposure to antimony trioxide may increase the risk of cancer. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. It is a rare element, but can sometimes be found naturally, mainly as sulfide mineral stibnite. 0 0. endstream endobj 24 0 obj <> endobj 25 0 obj <> endobj 26 0 obj <>/ColorSpace<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/ExtGState<>>> endobj 27 0 obj <> endobj 28 0 obj <> endobj 29 0 obj [/ICCBased 44 0 R] endobj 30 0 obj [/Indexed 29 0 R 15 45 0 R] endobj 31 0 obj <> endobj 32 0 obj <> endobj 33 0 obj <> endobj 34 0 obj <>stream It is insoluble in water. Little antimony is currently mined in the United States. Breathing air contaminated with antimony can cause eye and lung irritation, heart and lung damage, stomach pains, diarrhea, vomiting, and stomach ulcers. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. The primary hazard is the threat to the environment. Large doses cause vomiting, diarrhea, abdominal discomfort and tingling of the extremities. Hazard Summary. 0000007003 00000 n If the problem has been caused through the inhalation, ensure that the individual has fresh air to breathe.Â. endstream endobj 35 0 obj <>stream The fate and toxicity of this poorly soluble compound in soil is insufficiently known. Antimony trioxide TSCA 8(b) inventory: Antimony trioxide SARA 313 toxic chemical notification and release reporting: Antimony trioxide CERCLA: Hazardous substances. Antimony trioxide is a white crystalline solid. July 5, 2018 Another risk group for antimony exposure are patients suffering from schistosomiasis and leishmaniasis. Antimony trioxide is considered possibly carcinogenic to humans (Group 2B) by the IARC [150] and was recently listed as reasonably anticipated to be a human carcinogen by the NTP [151]. 0000002788 00000 n OSHA, IARC, and NTP do not classify antimony trioxide as a carcinogen. Immediate steps should be taken to limit its spread to the environment. Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardiotoxicity. 0000000016 00000 n Includes washing the stomach with sterile or saltwater to remove poison. 0000000796 00000 n The main signs are irritation of the respiratory tract and of the skin and a characteristic pneumoconiosis, which is visible on chest X-rays. It has also been listed as a possible human carcinogen by the International Agency for Research on Cancer. Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardio toxicity. Antimony trioxide (Sb2O3) is a widely used chemical that can be emitted to soil. Magnesium or selenium deficiency increase antimony absorption and retention in the body. Subchronic and chronic inhalation studies with rats and mice have demonstrated increased incidence of lung neoplasia following antimony trioxide exposure. 0000006312 00000 n In long-term animal experiments, rats exposed to antimony trioxide via inhalation showed a high frequency of lung tumours. Sections I (Health … * Prolonged or repeated contact can cause ulcers or sores in the nose. Antimony trioxide has suspected carcinogenic potential for humans. However, the effects will vary depending upon the amount and period of exposure. It is for educational purposes only. Zd> Antimony trioxide has suspected carcinogenic potential for humans. 0000002501 00000 n * Exposure to Antimony Trioxidecan irritate the nose, mouth, throat and lungs causing cough, wheezing and/or shortness of breath. High blood pressure, muscle break down, heart pain, Stomach and intestinal disorders (Fatigue, Gingivitis, Stomatitis), World Health Organization (WHO): 20 micrograms per liter (ug/L), S. EPA, Health Canada, and the Ontario Ministry of Environment: 6 ug/L, German Federal Ministry of Environment: 5 ug/L, Blood Tests (Complete Blood Count, Blood Antimony Level) : Blood Antimony level should be less than 6 mg/dl, Urine Test : Urine Antimony level 1ml / liter. In addition antimony trioxide is possibly carcinogenic to humans. These alloys are used in lead storage batteries, solder, sheet and pipe metal, bearings, castings, type metal, ammunition, and pewter. Chelation therapy with BAL, DMSA, or DMPS has been shown to improve antimony toxicity. 0000001141 00000 n Chronic exposure can lead to; antimony pneumonia, alterations in lung function, chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation. Elemental antimony metal does not affect human and environmental health. Toxicity can also result from repeated exposure to antimony in medications, such as tartar emetic (antimony and potassium tartrate), used to induce vomiting and in treatment of helminthic and fungal infestations. IRIS assessment development process. 23 25 Occupational exposure of Antimony includes individuals working with brake pad systems for heavy weight vehicles and port workers who are exposed to traffic on a daily basis. It accounts for 80% of total antimony in the USA used in the manufacturing of various consumer products.1 Human exposure to antimony trioxide occurs through ambient air, consumer products and workplace settings.1 2 In consumer products, it is commonly … 0000003114 00000 n : A860-100; A860-500 CAS-No 1309-64-4 Synonyms Antimony trioxide Recommended Use Laboratory chemicals. : Antimony trioxide . In accordance with the diantimony trioxide CSR, the NOAEL of 1686 mg/kg bw/d from a subchronic oral toxicity study in rats is selected as being the most relevant for estimating systemic effects that might be associated with dermal uptake of antimony metal or antimony (III) compounds. Despite the fact that large doses work as an emetic, if left untreated, a person may die. ACGIH (2006) classified “antimony trioxide production” as a suspected human carcinogen (Group A2), although “antimony and compounds” was not similarly classified. Antimony trioxide is used in the production of polyethylene terephthalate (PET) water bottles. It is brought into this country from other countries for processing. Symptoms of Excessive Antimony Exposure and Antimony Toxicity. The industrial use of antimony has not appeared to be … 0000008472 00000 n Antimony trioxide (Sb2O3) is a widely used chemical that can be emitted to soil. 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