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Accessed 29 June 2021. These vaccines have been found to be effective and safe in clinical trials with tens of thousands of participants, and in real world conditions with over 325 million doses administered. For more, see How safe are the vaccines?. The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions. Salk News - We made a big mistake, said Byram Bridle, a viral immunologist and associate professor at the University of Guelphs Ontario Veterinary College, during an interview with Canadian radio personality Alex Pierson on May 27. 01 Professor Juan Carlos Izpisua Belmonte is collaborating with According to his profile, Bridles research focuses on biotherapies for the treatment of cancers and the way organisms respond to viruses. The premise of this study is the Spike proteins are attaching to the epithelial cells that line our circulatory system. By: Express News Service The cells genetic machinery reads the mRNAs instructions, and any leftover mRNA is ultimately destroyed by the cell. It is not secreted and thus does not float through the body, McLellan said. If they are so safe, surely companies should have confidence in their products? therapies that express synthetic nanoparticles that seek, This is cellular biology 101. According to a statement sent to FactCheck.org by NIAID, if enough excess spike proteins are shed into the bloodstream and bind to human cells expressing the ACE2 receptor, an infected person could theoretically experience additional symptoms. My second instinct would be to blame any Fall/Winter surge in the UK and similarly here on variants. A new study co-led by Assistant Research Professor Uri Manor and UC San Diego shows that the proteins also play a key role in the disease itself. Lies tall mountains in which hidden within them lies a sea of water. A study out of Israel implies that prepping the immune system to expect the original COVID-19 may paradoxically put it at a disadvantage when exposed to the South African variant. During a SARS-CoV-2 infection, the NIAID told us, the virus spike proteins can latch onto human cells, allowing the virus to infect them. The vaccine allows the body to recognize spike proteins so it can learn to fight them, without the risk of a virus that can replicate spike proteins to the point of killing a person. COVID-19 Vaccine Research at U of G Awarded Provincial Funding. Ontario Veterinary College website. . , or VAERS, which is an early warning system run by the Centers for Disease Control and Prevention and FDA. . Simply put, there are too many VAERS adverse event reports to pass off all serious aftereffects as coincidence or to dismiss them as background rates. Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own. Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease LA JOLLAScientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. These include events that happen both in the womb as well as after birth. No Evidence Vaccine-Generated Spike Protein Lingers in Bloodstream, Bridle is taking our results and completely misinterpreting them, said. Are their other unknown factors that give them natural immunity? Expert groups continue to recommend use of the drug during pregnancy when necessary and in consultation with a doctor. DOI: 10.1016/j.isci.2023. Page number 45 from this PDF produced by Johns Hopkins University reveals that self-spreading vaccines already exist and are used to . For example, J&J isnt the only vaccine where blood coagulation disorders have occurred. This is not the first paper to show this, Magro (2020) showed this definitively.A synethetic mRNA gene is a great way to make spike proteins and cause damage because lipid nano-particles can travel into the brain whereas the virus does not. The same harmless mutation, called 2P, as in two proline molecules, is used in the SARS-CoV-2 vaccines. National Institute of Allergy and Infectious Diseases. Accessed 29 June 2021. MAN WAS CREATED BY GREAT INTELLIGENCE. The, , called 2P, as in two proline molecules, is, No Evidence Vaccine-Generated Spike Protein Is Harmful, prepared in response to the attention brought by the interview, Bridle says the Canadian government should be called upon to immediately halt the mass vaccination program of children and adolescents. He says there is no immediate threat of severe COVID-19 in the majority of Canadian children and adolescents, and that more safety and efficacy data is needed for the use of experimental vaccines., the use of the Pfizer/BioNTech COVID-19 vaccine in children 12 to 15, following authorization of the vaccine in youth 16 years old and older in December. That being said, most vaccines are essential for health but with these covid vaccines there has been a suspension of scepticism and government and corporate coercion that is extremely alarming. 02 The Lyumkis lab will also explore how the nonstructural . surfactant in COVID-19 patients. It is now known that many of the toxid effects of being infected by SARS COV 2 stem directly from the spike protein ie the spike protein itself is a pathogen. To use a vaccine that induces a persons cells to manufacture a pathogen in the trillions seems foolish on the face of it. 128, No. So by vaccinating people we are inadvertently inoculating them with a toxin., , Bridles research focuses on biotherapies for the treatment of cancers and the way organisms respond to viruses. He becomes clean !!!! SARS-CoV-2 virus RNA. It yielded the first COVID-19 vaccines. National Geographic. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Research. Health Canada authorizes use of the Pfizer-BioNTech COVID-19 vaccine in children 12 to 15 years of age. Press release, Government of Canada, Health Canada. On Point with Alex Pierson. Global News Radio. We discuss the paper, the authors' clarification. The vaccines were supposed to be staying in the arm where the recipient was jabbed but this is now known to be false. A lot of people think of it as a respiratory disease, but its really a vascular disease, says Assistant Research Professor Uri Manor, who is co-senior author of the study. Severe adverse reactions to the vaccines have been, , a viral immunologist and associate professor at the University of Guelphs Ontario Veterinary College, during an, interview with Canadian radio personality Alex Pierson, on May 27. Low, Jia Ming, et al. Thats because the SARS-CoV-2 spike protein is a shape-shifter. compare surfactant levels with the health outcomes of Any protein in the blood will get concentrated in breast milk, he said on the radio show. inflammatory proteins called cytokines, colloquially known as Why did he or she do it ? The 15-minute video shows three individuals discussing the COVID-19 vaccine and the spike protein is repeatedly described as "very dangerous" and "cytotoxic.". mimics the ones on the coronavirus. 03 In a separate study, in collaboration with pulmonary generating protective immunity. However, this is theoretical; the exact mechanism by which COVID-19 infection leads to cardiovascular symptoms is still unclear., Susan Weiss, a coronavirus researcher and professor of microbiology at the Perelman School of Medicine at the University of Pennsylvania, says there is not much virus in the blood following infection with SARS2., I am quite confident that the spike protein is not a toxin, she told FactCheck.org in an email. It would be nice for them to address it, but given millions vaccinated, apparently not. American Journal of Obstetrics & Gynecology. The information is. Most people dont show symptoms, but no one knows how damaged they body get. We thought the spike protein was a great target antigen, we never knew the spike protein itself was a toxin and was a pathogenic protein. Some immune cells latch onto the spikes and produce antibodiesY-shaped molecules that will recognize spike proteins and block them from getting inside other cells. test whether cytokines, like LIF, play a role in the immune I feel like there are a lot of propagandists showing up in the comments here. will target i) SARS-CoV-2 prevention by creating synthetic In fact, the antibodies that the mother has can go through the breast milk to the baby and may only serve maybe to protect the baby a little bit. The CDC and FDA vaccine safety monitoring systems, which were expanded for the COVID-19 vaccines and also include a new smartphone-based reporting tool called. The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape. 17 June 2021. Updated 21 June 2021. Its very safe, says WHOs Chief Scientist Dr. Soumya Swaminathan on a podcast produced by the organization. There is no damage when the spike protein is just inside a cell. With the live virus, the protein attaches to receptors on the surface of cells and fuses the viral membrane with the host-cell membrane, McLellan said. He posted a good link. [T]he spike protein from SARS-CoV-2 might be responsible for at least some of the damage that occurs in severe cases of COVID-19, he says, citing a study published in March in Circulation Research. You walk in the park and an infected person coughs near you, so you manage to get few virus particles but keep walking and breathing fresh air. The document was part of the submission data applied by Pfizer to PMDA (Japans version of FDA) for its review, and it is publicly available online, Ghazvini said. The goal of the project is to increase exposure to accurate information about COVID-19 and vaccines, while decreasing the impact of misinformation. 6. Her lab, in collaboration with The Scripps According to the NIAID statement, the spike protein is only detectable for a few days after immunization in tests conducted in animals. See: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/975909/S1182_SPI-M-O_Summary_of_modelling_of_easing_roadmap_step_2_restrictions.pdf. Experts say the spike protein created by the human body after mRNA vaccination is different than the SARS-CoV-2 spike protein. But authors of two of the studies he cites told us their findings dont back Bridles statements. Antisevere acute respiratory syndrome coronavirus 2 antibodies induced in breast milk after Pfizer-BioNTech/BNT162b2 vaccination. Ogata, Alana, et al.Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clinical Infectious Diseases. This binding disrupted ACE2s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented. Other immune cells will be activated that can seek out and destroy future coronavirus-infected cells displaying the spike. , COVID-19 Vaccination Considerations for ObstetricGynecologic Care. breastfeeding after vaccinations may provide babies with protection. Now, when the cell gets destroyed, all spike proteins which were produced shortly and did not become destroyed yet will float through your tissue and if you are unlucky, enter a blood vessel. combine CRISPR with an imaging technology, so that it will only A new study co-led by Assistant Research Professor Uri Manor and UC San Diego shows that the proteins also play a key role in the disease itself. while a professor at the Salk Institute, Holley shared the Nobel Prize for his work on how these . There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it. Spokesperson, Pfizer. Professors Clodagh OShea, Reply. Meanwhile, the Department of Justice is investigating myocarditis (inflammation of the heart) following cases in vaccinated service members. If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID, Manor explains. So far, your assumption is true. This has been shown to happen by researchers or doctors perfforming a D Dimr test on recently vaccinated people. How the mRNA vaccines work to fight COVID-19. Dr. Jeannie Kelly, an assistant professor of obstetrics and gynecology at the Washington University School of Medicine in St. Louis and lead author of a study on SARS-CoV-2 antibodies in breast milk following vaccination, told us there is no evidence to support Bridles claims. Accessed 29 June 2021. 10 June 2021. And what about those many numbers in the total population who contract the virus, recover with seemingly little damage if any to their vascular system? This has implications for many behaviors, including when its best to eat, exercise, and take medications. levels in the lungs alter the course of the disease. . CDC.gov. Nor is it known if one can have no visible symptoms but still have blood related disease that is not visible, or perhaps is not recognized for years. Kramer, Jillian. The studies included data from Sanofi-GlaxoSmithKline, Moderna and Pfizer-BioNTech vaccine constructs, incorporating the ancestral, Beta, Delta, Omicron BA.1 or Omicron BA.4/5 spike proteins . COVID Data Tracker. CDC.gov. Email sent to FactCheck.org. University of Guelph. Now, a major new study shows that they also play a key role in the disease itself. The majority of people wouldnt even know they had covid. There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it. In fact, the antibodies that the mother has can go through the breast milk to the baby and may only serve maybe to protect the baby a little bit. It also means that while naturally acquired immunity from the infection of SARS COv 2 will have targets from all different parts of the virus, the antibodies produced by the vaccine will only be active for small fragments of the transfigured spike protein induced by the vaccine mRNA. Retweet. Where,when,and how, the virus entered the human biological systems. No, thanks. Anyway after drinking this water.He got a different blood type than anyone on earth. Since the pandemic started, his lab has been trying to develop vaccines against coronaviruses, for which he received a $230,000 grant from the Ontario government. He will In the new study, the researchers created a pseudovirus that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. See: https://www.jpost.com/health-science/could-an-mrna-vaccine-be-dangerous-in-the-long-term-649253, If these spike proteins are expressed in endothelial cells, which are found in the vascular system, brain and other organs, the protein can presumably damage that tissue in a way that may not be readily apparent. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. NSP1 halts host protein production. Vol. My educated guess is this: Now that the vaccines are about to be used in kids as young as 12, I expect a more robust immune response and the presence of a better (faster) metabolism will translate into more immediate reports of adverse events among younger vaccine recipients the same group (with some exceptions!) Member of the faculty at Harvard Medical School and of Harvards Wyss Institute for Biologically Inspired Engineering. When the immune system recognizes the proteins, which arent normally there, it starts generating antibodies and building an immune response against them. 02 Creating a protective coronavirus vaccine is SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal modelproving that the spike protein alone was enough to cause disease. Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease, Home - Researchers detected levels of SARS-CoV-2 protein as early as one day after the first injection in 11 of the 13 participants. The spike protein is not pathogenic. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented. The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. And it is located upon a plateau. SciCheck Digest. See: https://pubmed.ncbi.nlm.nih.gov/33053430/ and https://pubmed.ncbi.nlm.nih.gov/33328624/, In Israel, where vaccination rates are much higher, myocarditis cases are under review for possible association with vaccination. currently one of the worlds greatest challenges. treatments using nanoparticles. The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xian Jiaotong University; and Xian Jiaotong University. of an individuals COVID-19 infection and limiting the virus . The mRNA vaccines builds the protein within the safe environment of the host cell structure from the inside outspikes are not created outside this environment. Accessed 29 June 2021. Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.. The study concluded lactating individuals should continue breastfeeding after being vaccinated. This treatment will prevent the virus Segments of the interview were widely spread in social media platforms in English and Spanish. That could explain why some people have strokes, and why some people have issues in other parts of the body. But theres absolutely no harm. Click link below to sign up for our monthly newsletter. Your mis-information is just as bad as some antivaxxers. The new technology treatments give mRNA to teach your own cells to make the spike proteins. This frees the (likely many) whole and partial spike proteins inside the cell into the blood. Yet, a Canadian virus immunologist recently claimed that the vaccines spike protein is a pathogenic protein, a toxin that gets into the bloodstream, then accumulates in breast milk and in a number of tissues and could lead to cardiovascular and neurological damage in adults, children and infants. Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together. See the next video and it becomes all clear. The spike protein, particularly the RBD, is therefore the main antigenic target for vaccine formulation. 01 In severe COVID-19 cases, immune cells in the infected windpipe and lungs can release high levels of damaging Watch this https://youtu.be/9EfToFXwx98?t=479, Wrong. Email sent to FactCheck.org. Its internationally renowned and award-winning scientists explore the very foundations of life, seeking new understandings in neuroscience, genetics, immunology, plant biology and more. COVID-19 vaccine for children. Statement, Canadian Paediatric Society. See: https://www.dailymail.co.uk/news/article-9366963/Coronavirus-Pfizers-Covid-vaccine-linked-blood-clots-AstraZenecas-UK.html. RNA-targeting CRISPR-Cas technology to destroy the See: https://www.regulations.gov/document/FDA-2020-N-1898-0246. Anyone can submit a report to VAERS for any health problem that occurs after an immunization. Of course, none of this even begins to account for how vaccines will alter our immune response, for better or for worse, to COVID-19 variants. That if one drink from it ! Keanna Ghazvini, a Pfizer spokesperson, told us in an email that the document referred to by Bridle, which is mostly in Japanese, is a pharmacokinetics overview of the companys vaccine. The CDC and FDA vaccine safety monitoring systems, which were expanded for the COVID-19 vaccines and also include a new smartphone-based reporting tool called v-safe, have subsequently identified only a few, very rare adverse events. (a pretty tall order) There is not enough of the viral matter in the vaccine to do significant harm without replication, which it cannot do. Theres been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Your support will accelerate the pace of breakthroughs in understanding disease and pave the way to new drug therapies. They say things like vaccines are perfectly safe which everyone knows is a blatant lie. You retards fell asleep in biology 101 of high school and it shows. BNT162b2 vaccination induces SARS-CoV-2 specific antibody secretion into human milk with minimal transfer of vaccine mRNA. medRxiv. Four years later, while a professor at the Salk Institute, Holley shared the Nobel Prize for his work on how these genetic molecules control protein synthesis. We are slowly getting to the right conclusion. Keep up with the latest scitech news via email or social media. In reality, Covid-19 is BOTH a vascular and a respiratory disease.