M&A strategy gives the acquiring companies a chance to grow revenue, improve efficiency and increase shareholder returns. UPDATE 1-U.S. says it is monitoring China's drills around Taiwan closely, Ex-BOJ deputy governor Nakaso predicts tweak or end to YCC -Nikkei, UK PM Sunak to meet U.S. President in Northern Ireland, UPDATE 2-Soccer-Lazio beat Juve 2-1 to cement second place, Housing market data suggests sector's downturn 'coming to an end'. Egetis confirmed rumors with a statement on Thursday while noting that there is no certainty that a takeover offer will be made. But TIGIT's an immune checkpoint inhibitor, so I think that would pair potentially quite nicely with Bristol-Myers Squibb's Opdivo. While the products being developed by Receptor Life are still several years away coming to market, they represent the potential for additional milestone payments and royalties as they work their way through the clinical trials process (and, knock on wood, commercialization at the end of said process). Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services. Heres a list of the largest: The mergers and acquisitions craze is being fueled by a few catalysts: Its expected that with the economy on warp recovery speed that M&A deals will continue to expand. Still, Cytokinetics was listed on Jefferies' M&A list as well as investor surveys by JPMorgan, Mizuho, and RBC. As has been the case for a number of years now, MNKD is considered a very strong buy under $5 and a buy under $10. Albireo Therapeutics (ALBO): Odevixibat candidate for the development of treatments for disorders associated with irregularities in bile acid biology. BioNTech will pay Shanghai-based Duality Biologics $170 million upfront for rights to two of its topoisomerase-1 inhibitor-based antibody drug conjugates. The biotech industry could use the much-needed jolt. Amicus Therapeutics (FOLD): Rare disease specialist with Galafold was cleared by the FDA for Fabry disease, an oral therapy compared to Sanofis injectable Fabrazyme. What makes this stock so interesting is that Simufilam appears to improve cognition in Alzheimers patients, not just slow the progression of the disease. The primary endpoints were the reduction in the decline of cognition (ADAS-COG) and activities of daily living (ADCS-ADL) at 48 weeks. The drug could go toe to toe with gene therapies being developed by companies like Bluebird Bio and Vertex Pharmaceuticals, Tewari added. But Jefferies analysts and investors surveyed by JPMorgan think Vertex could be the one to be acquired. While the data already released was superior to lecanemab, once the 50 mg alone cohort data comes out the results should be considerably better than for the combined group. Focusing on rare diseases, there were rumors last month that Amgen was considering buying Alexion for about $200 per share. We expect other pharma companies to follow suit to boost their pipeline amid rising competition and dwindling sales of legacy drugs. Some have merit and turn out to be true, while others turn out to be false and They also have a partnership for some pre-clinical products, which I think if Vertex made the acquisition, it could accelerate that and put that as a higher priority. 2022 M&A activity in the life sciences sector failed to meet expectations, but Amgens recent $26.4 million buy-out of Horizon Therapeutics may be a sign of Click to get this free reportBioMarin Pharmaceutical Inc. (BMRN) : Free Stock Analysis ReportuniQure N.V. (QURE) : Free Stock Analysis ReportREGENXBIO Inc. (RGNX) : Free Stock Analysis ReportDeciphera Pharmaceuticals, Inc. (DCPH) : Free Stock Analysis ReportTo read this article on Zacks.com click here. Jefferies and RBC both listed Arrowhead on their M&A lists. Specifically, Seagen has an anti-TIGIT antibody. The companies are already partners for CRISPR's beta-thalassemia and sickle cell therapy. See disclosure here. Last month, Adaptimmune announced that SPEARHEAD-1 trial evaluating afamitresgene autoleucel (afami-cel, formerly ADP-A2M4) in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) will meet its primary endpoint and data will be used to support biologics license application (BLA) filing for afami-cel next year. The firm's analysts expect there will be 15 to 20 deals announced this year. Neurocrine Biosciences Moreover, companies investing in mRNA technology are gaining a lot of attention, given the success of the technology in the development of COVID-19 vaccines. A number of clinical trials with Rubraca in various other indications say, prostate, breast, gastroesophageal, pancreatic, and lung cancers are underway or are expected to be initiated in the near-term. They just revealed what they believe are the ten best stocks for investors to buy right now and Bristol Myers Squibb wasn't one of them! I don't know, maybe they could out-license those. There weren't that many biotech acquisitions in 2021, at least, not compared to other previous years. Awaiting approval for one indication (progressive familial intrahepatic cholestasis, or PFIC) in the second half of this year, and is undergoing Phase 3 trials for two others. Nancy Zambell has spent 30 years educating and helping individual investors navigate the minefields of the financial industry. Some analysts say 2022 could be the year Vertex bounces back. Mike did a little buying this week and is hoping to add more should the market be able to build on the recent action. Therefore, results yet to come should be even better once the company reports on the 50 mg cohort by itself. BioMarin Pharmaceutical the first one in 2013. Orelli: I think a pharma that wanted a lot of cash flow, but also wanted to boost up their pipeline, Vertex probably has more external deals than it has internal candidates. Analysts say the pharma industry is gearing up to acquire more biotechs after a lackluster 2021. Tien Tzuos Leadership Propels Zuoras 14% Growth In Subscription Economy. Global M&A has hit a record $2.4 trillion, up 158% over 2020, according to a Refinitiv Deals Intelligence reportthe highest since the company began collecting data in 1980. I certainly hear related complaints about these issues in my medical practice on a regular basis. We've just talked about two deals that have been announced this week. The pipeline progress has been encouraging. Like the Medicines Co., Amarin also has a heart drug by the name Vascepa in its kitty. Brian, what are some acquisitions that you'd like to see take place in the biopharmaceutical world in 2022. Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. It was also approved in the EU. Want the latest recommendations from Zacks Investment Research? Outsmart the market with Smart Portfolio analytical tools powered by TipRanks. Biocom California, the association representing the life science industry of California, issued the following statement regarding their application to intervene in support of Illuminas challenge to the European Commissions jurisdiction over the acquisition of GRAIL. REGENXBIO Inc. price | REGENXBIO Inc. Quote. If you're going to give me a quick up-front profit, I'm definitely going to take it and I'm not going to complain about it. Mergers and acquisitions have roared back this year, with potential takeover targets everywhere. Ally Biotech, a science-based company and provider of leading-edge bioactive cannabinoid delivery solutions, today announced the acquisition of the popular Mergers and acquisitions have roared back this year, with potential takeover targets everywhere. BioMarin was listed on Jefferies' and JPMorgan's M&A lists. By exercising its option to purchase Alterola's remaining issued and outstanding common stock over the coming months, Bright Green will complete the acquisition using Bright Green common stock. But Trikafta enjoys a first-mover advantage and currently faces limited competition in the cystic fibrosis market. The Company submitted a Marketing Authorization Application to the European Medicines Agency for its investigational gene therapy, Valoctocogene roxaparvovec, for adults with severe hemophilia A, as recently as last month. Youre reading a free article with opinions that may differ from The Motley Fools Premium Investing Services. Two years ago, operations at Vertex began shifting. Those two should keep the numbers kiting higher, with analysts seeing the top line rising 20% next year while earnings reach nearly $4 per share all while the firms excellent pipeline continues to progress. Admittedly, relying on one product for so much revenue adds risk to the stock. Spiral Therapeutics, Inc. ("Spiral"), a clinical-stage company focused on delivering therapies for inner ear disorders, announced today the completion of its acquisition of selected assets from Otonomy, Inc. Coeptis Therapeutics Holdings, Inc. (NASDAQ: COEP) ("Coeptis" or "the Company"), a biopharmaceutical company developing innovative cell therapy platforms for cancer, announced it has obtained the exclusive right to negotiate towards the acquisition of VyGen-Bio, Inc. or its assets. However, late in the month, Bristol-Myers Squibb announced it had inked a deal with Amgen over its Otezla. INCY has gained 43% year-to-date and trades around $91. (Still a big target market.) Cost synergies in research and development (R&D) plus sales and marketing are also added benefits. Ally Biotech, a science-based company and provider of leading-edge bioactive cannabinoid delivery solutions, today announced the acquisition of the popular Chill Pill brand, an extensive line of soft, easy-to-swallow soft gel caps and all of its assets, from Desert Medical Campus, in an all-cash transaction. Some have merit and turn out to be true, while others turn out to be false and without merit. Signs Layoffs may be Coming Soon at Your Job. Stay up to date with what you want to know. Perhaps the most important fact to consider is that as the population ages and chronic conditions such as diabetes increase, so does the incidence of incontinence. They could develop that in combination. The companys stock is up 5.6% so far in 2020. Good News For Black Workers And A Goldilocks Job Market Are Good News For The Economys Stability, Eras Tour Could Net Taylor Swift $500 Million To $1.5 Billion. No. Here's How to Turn It Into a Lucrative Passive Income Stream, Join Over Half a Million Premium Members And Get More In-Depth Stock Guidance and Research, Motley Fool Issues Rare All In Buy Alert, Copyright, Trademark and Patent Information. Updated March 13, 2023 By Jacob Bell In the business of drug development, deals can be just as important as scientific breakthroughs. Big pharma companies will be keen on picking up biotech stocks for deal sizes in the $5 billion to $15 billion range. The quest behind the drive is to fill potential gaps in the pipeline. PwC also expects large-sized deals, valued at $50 billion or more, for diversifying into adjacent therapeutic areas. All of this business versatility could make Horizon a good buyout option, according to Jefferies analysts and investor surveys conducted by JPMorgan and Mizuho. That remains to be seen. But other times, the rumor fizzles along with the recent stock price gains. Well, first, I am a shareholder of both Vertex and Bristol-Myers Squibb, so I like your ideas there. Other approved drugs in the companys portfolio continue to do well. Incyte has an attractive pharmaceutical portfolio comprising of Jakafi, a blockbuster drug for rare blood cancer indications, and 3 other marketed drugs, and a well-stocked pipeline. I think Adicet might be a good fit for Gilead, as it's developing off-the-shelf CAR-T therapies. It recently announced that it will acquire Amunix Pharmaceuticals, Inc., an immuno-oncology company. The COVID-19 pandemic resulted in a shift in focus to development of vaccine and treatments for the deadly disease, which has taken 1.65 million lives so far. Rubraca competes with other PARP inhibitors like Lynparza and Zejula. BioMarin has a Zacks Rank #3 (Hold). In addition, a private company called Receptor Life Sciences has licensed the company's Technosphere drug delivery system to develop cannabinoid products for epilepsy and anxiety. 2 Top Healthcare Stocks to Buy for the Long Haul, Got $5,000? Medigene (MGD1.DE/MDGEF): German company partnered with bluebird bio Inc. on TCR-modified T-cell programs for multiple indications, including intracellular tumor antigens that arent addressable with CAR-T therapeutics. This therefore limited what the company could accurately report at that time. Right now, investors in these companies have a shot at serious profits. This product (Tyvaso DPI) has only been on the market for a few months, but it is already showing signs of becoming a blockbuster. Peak Pharmaceuticals, Inc. (OTC Pink:PKPH) ("Peak" or the "Company"), announced that it has merged with Retrieve Medical, Inc., a software company that is commercializing a patented Clinical Documentation Improvement (CDI) platform, Retrieve DxTM, that enhances physicians' ability to quickly understand the complex clinical history of patients and diagnose chronic conditions by analyzing physician notes, lab results, radiology reports, EKG interpretations and more. Invest better with The Motley Fool. Are some major acquisitions on the way in the biopharmaceutical industry this year? And more to the point: Treatment with ANAVEX2-73 statistically significantly reduced cognitive decline, measured with ADAS-Cog, compared to placebo at end of treatment by 45% (p=0.033).. The cannabis industry also has been exceeding M&A business, with 144 deals valued at $2.8 billion in the U.S. Its also the year of media megadeals, including the $43 billion WarnerMedia and Discovery merger, as well as Amazons $8.5 billion purchase of famed studio MGM. *Average returns of all recommendations since inception. To read this article on Zacks.com click here. Nonetheless lecanemab's meager result caused those two companies to increase $20 billion in market cap overnight. About 87% of investors, for instance, expect an increase in mergers and acquisitions compared with last year, according to a JPMorgan survey conducted from November 22 to December 3. Pharma giants are expected to end 2022 with as much as $500 billion in cash, according to analysts. The COVID-19 outbreak has shifted consumer behavior dramatically, and a handful of high-tech companies have stepped up to keep America running. BMRN briefly touched $100.13 on February 5, 2019. This company is a promising player in the gene therapy space. So I think the data so far was encouraging, but the best news is yet to come and the stock remains a favorite for 2023. BioMarin is almost every analyst's favorite takeover candidate. Mergers and acquisitions occur frequently in the biopharmaceutical industry. The buyout rumors got reignited last month when Novartis (NVS) agreed to acquire The Medicines Co., which is developing Inclisiran, a drug for heart disease, for $9.7 billion. The quest behind the drive is to fill potential gaps in the pipeline. Transcat, Inc., a leading provider of accredited calibration services, enterprise asset management services, and value-added distributor of professional grade handheld test, measurement and control instrumentation, announced that it has purchased all of the capital stock of privately-held TIC-MS, Inc., effective March 27, 2023. Regulators asked for more data on its lead cancer drug before reviewing it; Maria Fardis resigned as CEO; and the biotech's share price fell more than 50% on the year. Insiders apparently think Simufilam works, because two Directors spent their hard earned cash buying the stock in August of 2022. Bristol-Myers Squibb (BMY) acquiring Celgene for $74 billion in January remains the most expensive acquisition of this year. There would be some synergies on the commercial sales side. Apart from RGX-314, the company is also developing three other gene therapy candidates for treating certain rare neurological symptoms. But following Gilead's decision to acquire Kite Pharma in August of that year, the rumors died down. Alexion Pharma is no stranger to takeover rumors. Got $1,000? Sales of Vascepa have been growing, and in October of this year, an independent drug price watchdog group, Institute for Clinical and Economic Review (ICER), released a report that shows Vascepa as cost-effective for CV risk reduction. Its not unusual for rumors of a buyout offer to emerge a couple of days before the actual offer. AMRN closed Friday's trading at $24.12, up 4.92%. If Iovance can get clarity with the Food and Drug Administration on what's needed to file for approval, Mizuho analysts wrote that the biotech is "an interesting add-on to companies with hospital-based drug oncology franchises.". Alexion Pharmaceuticals. WebIn the ongoing saga of whether Merck will acquire formidable biotech Seagen, the companies have scheduled a meeting this week, sources Amid M&A rumors, Merck and Seagen set to meet: WSJ Fierce Pharma All rights reserved. Sure enough, this is not glamorous stuff. It remains to be seen if the takeover rumors are just wishful thinking or will turn into reality. WebPfizer, for one, could see $84 billion in total sales from its BioNTech-partnered COVID vaccine Comirnaty and its yet-to-be-authorized oral antiviral Paxlovid between 2021 I don't know. The big news for Anavex was the release of the preliminary data from the 508 patient, placebo controlled, double-blind, 48-week, Phase 2b/3 ANAVEX 2-73 (blarcamesine or A2-73) Alzheimers trial which tested 3 equal cohorts with placebo, 30 mg or 50 mg oral doses. But now, the stock is acting well and we expect it to continue strongly on an upward path. , first, I am a shareholder of both Vertex and Bristol-Myers Squibb it. By the name Vascepa in its kitty talked about two deals that been... $ 5,000 come should be even better once the company is a promising player the... Jpmorgan, Mizuho, and more from the Motley Fool 's premium services: Odevixibat candidate the... 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